namespace Buttons
{
    /// <summary>
    /// Interaction logic for MainWindow.xaml
    /// </summary>
    public partial class MainWindow : Window
    {
        public MainWindow()
        {
            this.Initialized += OnInitialized;
            this.InitializeComponent();
        }

#if NOESIS
        private void InitializeComponent()
        {
            Noesis.GUI.LoadComponent(this, "MainWindow.xaml");  // My breakpoint here is hit
        }
#endif

        private void OnInitialized(object sender, EventArgs args)
        {
            this.DataContext = new ViewModel();
        }

        protected override bool ConnectEvent(object source, string eventName, string handlerName)
        {
            return base.ConnectEvent(source, eventName, handlerName);  // I set my breakpoint here but it's not hit
        } 
    }
}

<Button Content="Start" Click="OnStartButtonClicked"/>