Repro Steps:

1) Create a Page
2) Create any Path using the Path Tool (P). Ideally this is an irregularly shaped Path to better visualise the rotation that will be applied in Step 4).
3) Using the Path Selection Tool (A), select any Path Point, and use [Shift+ArrowKeyLeft] to nudge the Point a couple tens of pixels to the left.

4) Select the Path, and in its properties, navigate to its Render Transform properties, set its Transform Origin to Centre, then set its rotation to -180
5) Using the Path Selection Tool (A), select any Path Point, and use [Shift+ArrowKeyLeft] to nudge the Point a couple tens of pixels to the left.

Observe how the Path Point moves in the opposite direction (to the right, instead of the left)

Expected Results: Just as dragging a Path Point to the left using the mouse click-and-drag, moves the Path Point to the left, the same mechanic should apply to ArrowKey position changes of Points, in that left Arrow always moves a point to the left within the stage (and likewise with Right, Up, and Down.)